ARS—the enzyme working in the center of life

Aminoacyl-tRNA synthetases

All living organisms are operated, without exception, by the flow of genetic information to the production of protein through translation.

In addition to their catalytic function, aminoacyl-tRNA synthetases (ARSs) are associated with angiogenesis, inflammation, tumorigenesis, and other important pathophysiologic processes in human diseases.

The roles and implications of ARSs in human diseases and drug discovery have been largely overlooked for decades.

Aminoacyl-tRNA synthetases
ARS multiple drug delivery routes

ZYMEDI harnesses the noncatalytic regulatory roles of ARS as a novel therapeutic target

ARS plays an essential role in maintaining the balance of homeostasis in life.

With their functional diversity and disease association, ARSs are emerging as a promising target for novel therapeutics for infectious disease areas.

ARS offers multiple routes for novel drug discovery. The functional versatility of ARSs warrant multiple therapeutic routes:

ARS multiple drug delivery routes
  • ROUTE 1: seeks unique pharmacological efficacy by targeting the catalytic site

  • ROUTE 2: explores therapeutic opportunity from extracellular ARSs

  • ROUTE 3: intervenes the disease-associated protein-protein interactions between human ARSs and their interactors

Our platform uses a deep understanding of ARS biology to change how diseases are viewed.

Contact ZYMEDI

We welcome joint ventures, strategic investors, and in-licensing partners who want to be part of our mission to identify novel therapeutics for hard-to-treat disease areas. To learn more, or to partner with ZYMEDI, contact us today.